Maintenance DNA methylation is essential for regulatory T cell development and stability of suppressive function
نویسندگان
چکیده
منابع مشابه
Human Regulatory T Cell Suppressive Function Is Independent of Apoptosis Induction in Activated Effector T Cells
BACKGROUND CD4(+)CD25(+)FOXP3(+) Regulatory T cells (Treg) play a central role in the immune balance to prevent autoimmune disease. One outstanding question is how Tregs suppress effector immune responses in human. Experiments in mice demonstrated that Treg restrict effector T cell (Teff) responses by deprivation of the growth factor IL-2 through Treg consumption, resulting in apoptosis of Teff...
متن کاملHuman natural regulatory T cell development, suppressive function, and postthymic maturation in a humanized mouse model.
CD4(+) regulatory T cells (Tregs) control adaptive immune responses and promote self-tolerance. Various humanized mouse models have been developed in efforts to reproduce and study a human immune system. However, in models that require T cell differentiation in the recipient murine thymus, only low numbers of T cells populate the peripheral immune systems. T cells are positively selected by mou...
متن کاملGranzymes are necessary for suppressive function of regulatory T cells
Purpose Regulatory T (Treg) cells are an essential subset of CD4+ T cells that induce and maintain immunological tolerance. Preclinical animal models have demonstrated that adoptive transfer of Treg cells can prevent or cure diabetes, multiple sclerosis (EAE), inflammatory bowel disease, lupus, arthritis, and graft versus host disease. Defects in Treg cell function and number have been describe...
متن کاملDGCR8-Mediated Production of Canonical Micrornas Is Critical for Regulatory T Cell Function and Stability
Regulatory T cells (Treg) are integral for immune homeostasis. Here we demonstrate that canonical microRNAs (miRNAs) are required for Treg function because mice with DGCR8-deficient Treg cells spontaneously develop a scurfy-like disease. Using genetic lineage marking we show that absence of miRNAs leads to reduced FoxP3 expression in Treg cells in vivo. In vitro culture of purified DGCR8-defici...
متن کاملInsufficient maintenance DNA methylation is associated with abnormal embryonic development
BACKGROUND Early pregnancy loss (EPL) is a frustrating clinical problem, whose mechanisms are not completely understood. DNA methylation, which includes maintenance methylation and de novo methylation directed by DNA methyltransferases (DNMTs), is important for embryo development. Abnormal function of these DNMTs may have serious consequences for embryonic development. METHODS To evaluate the...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2020
ISSN: 0021-9738,1558-8238
DOI: 10.1172/jci137712